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Quatrefolic® represents an innovative dietary ingredient designed to act as a nutrient in all areas where folic acid and folate supplementation has been recommended and allowed. Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the reduced and active form of folic acid. Developed by Gnosis S.p.A, it represents the fourth generation folate providing greater stability, higher water solubility and multiple ingredients formulation flexibility compared to 5-methyltetrahydrofolate calcium salt guaranteeing an improved bioavailability.